Vernier cam wheels and knowing you can swing the cams 100 to 120 without piston to valve or valve to valve contact helps. You can go up to 10:1 with 97 octane plus and FI. You want flat top or minimal piston domes if you go up on compression. I would not do this with a carb and clockwork distributor!
I'm planning on moving towards a wasted spark or sequential mapped system, as I don't want to continue using the cam-driven distributor I am using now. Even so 10:1 might be a little hard to control fuel distribution in #4. What do you think?